49ers Favored Over Cowboys in Week 10 Prediction Markets

The San Francisco 49ers are positioned as the clear favorites in prediction markets for their upcoming National Football League Week 10 matchup against the Dallas Cowboys. According to data from Polymarket, the 49ers have a 66 percent probability of winning the contest, while the Cowboys are assigned a 34 percent chance of victory. These odds reflect the current form of both teams as the 2026 season progresses into its critical middle stretch.

The 49ers have maintained a high level of offensive production despite dealing with various injuries. The performance of quarterback Brock Purdy, running back Christian McCaffrey, and tight end George Kittle has kept the team competitive. San Francisco currently ranks sixth in the league in yards per game and third in scoring offense. The team has also received a boost with the acquisition of Keenan Allen at the trade deadline and the return of Deebo Samuel to practice. The 49ers defense has also shown improvement, currently ranking sixth in points allowed per game.

Conversely, the Dallas Cowboys possess one of the most explosive offenses in the league, averaging 27.3 points per game. However, this offensive firepower has not yet translated into wins against the league's top teams. The Cowboys defense ranks 30th in yards allowed per game and 26th in points allowed per game, which presents a significant challenge. Quarterback Dak Prescott continues to perform at a high level, and the potential return of wide receiver George Pickens could create additional opportunities for CeeDee Lamb.

The SportsLine Projection Model, which simulates every NFL game 10,000 times, has San Francisco prevailing in 56 percent of its simulations for this matchup. The model has maintained a strong record for top-rated picks dating back to 2024. In the prediction market, the odds for a 49ers win stand at 66 percent, while the odds for a Cowboys win are 34 percent.

Beyond the outright winner, market participants can also trade on the margin of victory. The odds for the Cowboys to either win or lose by fewer than 4.5 points are set at 53 percent for a 'Yes' outcome. This is compared to 48 percent for the proposition that San Francisco will win by more than 4.5 points. Six of San Francisco's seven wins this season have been by more than 4.5 points, with the exception being a three-point victory over the Seattle Seahawks.

Regarding the total points scored, the market leans toward an offensive contest. The odds for the combined score to exceed 55.5 points are 52 percent, while the odds for the game to finish with fewer than 55.5 points are 49 percent. The SportsLine model predicts these teams will top the 55.5-point mark in 64 percent of simulations, largely due to the vulnerabilities in Dallas' defensive structure.

Polymarket offers various risk management tools for users, including trading breaks, voluntary opt-out features, and funding limits. Prediction markets are regulated by the Commodity Futures Trading Commission, an independent agency of the U.S. federal government. Participants should note that event contracts trading involves a risk of substantial loss and is subject to applicable eligibility requirements and jurisdictional laws.

New users can access a $25 bonus by using the promo code CBSSPORTS after depositing at least $10. This offer is available to those looking to engage with the prediction markets for this pivotal rivalry game. Fans should ensure they are in an eligible state and review the terms and conditions before making a deposit to participate in the trading.